Session Introduction
نویسندگان
چکیده
Small regulatory RNAs are a class of non-coding RNAs that function primarily as negative regulators of other RNA transcripts. The principal members of this class are microRNAs and siRNAs, which are involved in post-transcriptional gene silencing. These small RNAs, which in their functional form are singlestranded and ~22 nucleotides in length, guide a gene silencing complex to an mRNA by complementary base pairing, mostly at the 3’ untranslated region (3’UTR). The association of the silencing complex to the conjugate mRNA results in silencing the gene either by translational repression or by degradation of the mRNA. The discovery of microRNAs and their regulatory mechanism has been at the center of a dogmatic shift of our view of non-coding RNAs and their biological role.
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